Fig. 7
From: Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis
Blnc1 inactivation suppresses the molecular signature of diet-induced NASH. a Heat map representation of upregulated and downregulated genes identified in RNAseq analysis of the livers from NASH-fed mice. b Enrichment score for downregulated (blue) and upregulated (yellow) genes. c qPCR analysis of hepatic genes involved in lipid metabolism from ctrl (filled, n = 6) and LKO (open, n = 6) mice fed NASH diet for 24 weeks. d Immunoblots of total liver lysates and liver nuclear extracts from NASH-fed mice. e qPCR analysis of hepatic genes involved in inflammation and fibrosis. Data in (c) and (e) represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.01; ctrl vs. LKO, two-tailed unpaired Student’s t-test
