Fig. 6
From: Directed evolution of CRISPR-Cas9 to increase its specificity
On-target and off-target activities of WT-Cas9 or Sniper-Cas9 paired with a gX19 guide RNA targeting AAVS and delivered via RNP into iPS cells and T cells. Specificity ratios were determined by dividing the on-target activity by the off-target activity. (−) indicates the absence of RNP. Error bars indicate s.e.m. (n = 3)
