Fig. 4 | Nature Communications

Fig. 4

From: Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Fig. 4

pQTL-protein-coronary heart disease network. Network of proteins and significant pQTL variants that are also GWAS risk SNPs for CHD. For proteins with multiple pQTL variants that coincide with CHD GWAS SNPs, the pQTL variant with the lowest P value of association with its corresponding protein level is shown. The following two conditions are summarized: (1) Proteins that tested causal for CHD in Mendelian randomization (P < 0.05). (2) Proteins associated with new-onset major CHD/CVD events (P < 0.0038) in 3520 Framingham Heart Study participants 50 years of age or older with long-term follow-up. Proteins in green fulfill neither condition 1 nor 2; proteins in blue fulfill condition 1; proteins in red fulfill condition 2; proteins in purple fulfill conditions 1 and 2. CHD coronary heart disease, FHS Framingham Heart Study, MR Mendelian randomization, pQTL protein quantitative trait locus

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