Table 1 Proteins with pQTL variants that coincide with coronary heart disease-associated SNPs from Genome-wide Association Studies

From: Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Measured protein

pQTL varianta

Location

pQTL-annotated gene

pQTL-protein association

pQTL-CHD association

Effect allele

EAF

Beta

P value

Beta

P valuec

APOB

rs7412

19:45412079

APOE

T

0.076

−0.54

9.62E−53

−0.14

8.17E−11

APOB

rs12740374

1:109817590

CELSR2

T

0.215

−0.18

4.95E−16

−0.11

4.63E−23

B2M

rs10774625

12:111910219

ATXN2

A

0.497

0.12

8.66E−11

0.067

2.69E−10

CRP

rs12721051

19:45422160

APOC1

C

0.851

0.23

2.39E−17

−0.091

1.98E−10

GMP140

rs507666

9: 136149399

ABO

A

0.818

−0.43

1.11E−72

0.080

1.64E−11

GRN

rs12740374

1:109817590

CELSR2

G

0.215

0.75

2.72E−268

0.11

4.63E−23

LPA

rs55730499b

6:161005610

LPA

C

0.939

−1.25

3.77E−167

−0.32

4.66E−09

MCAM

rs507666

9: 136149399

ABO

A

0.185

−0.16

2.45E−11

0.079

1.64E−11

sGP130

rs507666

9: 136149399

ABO

A

0.186

−0.21

1.68E−18

0.079

1.64E−11

sICAM1

rs507666

9: 136149399

ABO

A

0.185

−0.32

4.39E−42

0.079

1.64E−11

  1. EAF effect allele frequency, CHD coronary heart disease, pQTL protein quantitative trait locus
  2. aFor proteins with multiple pQTL variants that coincide with coronary heart disease GWAS SNPs, the pQTL variant with the lowest P value of association with its corresponding protein level is shown
  3. bIndicates cis-pQTL. All other pQTLs shown in this table are trans-pQTLs
  4. cP value of associations with coronary heart disease risk in GWAS reported in the CARDIOGRAMplusC4D Consortium
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