Fig. 6

Deficient ILCs in CD4 lymphopenic HIV/SIV-uninfected human and nonhuman primates. a Frequencies and b absolute numbers of ILC subsets in blood of uninfected control animals (N = 9), animals receiving DSS (N = 2), or animals experimentally depleted of CD4 T cells with (N = 5) or without DSS treatment (N = 5). c Frequencies of ILCs in MLN of healthy control, SIV-uninfected DSS-treated, αCD4-treated, or animals receiving both treatments. d Frequencies and e absolute numbers of blood ILCs in healthy (N = 10) and ICL (N = 11) human subjects. Correlation between f NKp44⁻ ILC3 and g NKp44⁺ ILC3 percentages and CD4 T cell percentage in the MLN of SIV⁺ RMs. Statistical significance was calculated using the Mann–Whitney test. A Pearson's correlation was calculated for panels f, g. ns = P > 0.05, * = P ≤ 0.05, ** = P ≤ 0.01, *** = P ≤ 0.001, and **** = P ≤ 0.0001