Fig. 2
From: HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
HIF-1α and HIF-2α peptides bind VBC complex with a similar motif. a Alignment of HIF-1α and HIF-2α proteins from various species. *denotes the primary hydroxylation site. ^denotes residues that are not conserved between human HIF-1α and HIF-2α. Residues shaded in yellow are conserved in at least two out of three species for that protein. b Model of pVHL-elongin B-elongin C-HIF-2αOH complex. HIF-2α is shown as a stick model in light blue. pVHL (green)-elongin B (pink)-elongin C (yellow) are displayed as a van der Waal surface. c, d Crystal structures of pVHL-elongin B-elongin C-HIF-1αOH complex (1LQB) and pVHL-elongin B-elongin C-HIF-2αOH complex are superimposed. Carbon is shown in green (HIF-1α) or light blue (HIF-2α), oxygen is shown in red, nitrogen is shown in blue, and sulfur is shown in yellow
