Fig. 1 | Nature Communications

Fig. 1

From: Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity

Fig. 1

Coating tumor cells in situ with endogenous polyclonal antibodies. a Hapten-specific polyclonal antibody response is elicited in mice by vaccination, for example, by vaccination against DNP. The vaccinated mice are then administered with the said hapten conjugated to a tumor targeting ligand, for example, an oligonucleotide aptamer, that recognizes a product that is preferentially expressed on the tumor cells (receptor). Consequently, the hapten will accumulate in the tumor and attract the preformed polyclonal antibodies, essentially “coating” the tumor cells with antibodies. The antibody-coated tumor cells will in turn attract Fc receptor expressing phagocytic and dendritic cells, resulting in ADCC-, ADCP-, complement-dependent lysis or uptake and processing for antigen presentation, respectively

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