Fig. 6 | Nature Communications

Fig. 6

From: Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity

Fig. 6

Targeting αGal trisaccharide to tumor cells. αGal-null (C57BL/6xDBA/2Jx129sv GT−/−) mice were vaccinated with pig kidney extracts to boost the titer of anti-αGal antibodies and 10 day later challenged subcutaneously with 5 × 105 αGallow/negative B16BL6 tumor cells. 3 days post tumor implantation mice were treated with VEGF–DNP or VEGF–αGal hapten conjugates and tumor growth was measured. a Tumor volume. Statistical analysis: VEGF–αGal in VAC versus naive, ***p = 0.0037, Student’s t-test. b Time to tumor appearance. Statistical analysis: VEGF-αGal in VAC versus naive or any other group, p < 0.0001, Log-rank test for significance. (7 mice per group) (n = 2). Data are represented as mean ± SEM

Back to article page