Fig. 5
From: Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
Substrate/metal binding and proposed enzymatic mechanism of DrdA. a Manganese binding coordination of unliganded and liganded DrdA; the substrate DHAP replaces the coordinating Glu76. b Active site surface representation showing the binding pocket for the acceptor, aldol substrate in DrdA and FucA (PDB code 4C24). c Mechanistic proposal for DrdA-catalyzed formation of the enediol intermediate along with release of acetaldehyde
