Table 3 Brain white matter differences in MAP1B LoF carriers compared with controls
From: MAP1B mutations cause intellectual disability and extensive white matter deficit
White matter | MAP1B-FS | Controls-FS | β (95% CI) | P |
|---|---|---|---|---|
Corpus callosum—anterior—volume | 431.3 (155.9) | 900.2 (153.7) | −2.6 (−3.4, −1.9) | 1.9 × 10−11 |
Corpus callosum—posterior—volume | 472.9 (141.4) | 988.6 (156.7) | −2.5 (−3.3, −1.8) | 1.0 × 10−10 |
Corpus callosum—total—volume | 1689.3 (426.4) | 3210.3 (486.3) | −2.4 (−3.2, −1.7) | 5.5 × 10−10 |
LH—Cerebral white matter—volume | 190965.3 (23104.5) | 250084.3 (30115.5) | −2.2 (−2.9, −1.4) | 4.0 × 10−08 |
Total cerebral white matter—volume | 382905.6 (46892.5) | 502178.8 (60387.8) | −2.1 (−2.9, −1.4) | 5.1 × 10−08 |
RH—cerebral white matter—volume | 191940.3 (23831.4) | 252094.6 (30354.8) | −2.1 (−2.9, −1.3) | 6.8 × 10−08 |
Corpus callosum—central—volume | 268.2 (56.6) | 438 (87.7) | −1.9 (−2.7, −1.1) | 1.1 × 10−06 |
Corpus callosum—mid-posterior—volume | 245.2 (60.4) | 424.7 (92.3) | −1.8 (−2.6, −1.0) | 4.7 × 10−06 |
Corpus callosum—mid-anterior—volume | 271.8 (80.5) | 458.8 (103.6) | −1.8 (−2.5, −1.0) | 4.8 × 10−06 |
LH—white matter surface area | 75187.5 (8576.7) | 85866.9 (8321.5) | −1.5 (−2.3, −0.8) | 7.9 × 10−05 |
RH—white matter surface area | 75488.3 (8865.8) | 86285.6 (8411.9) | −1.5 (−2.3, −0.8) | 8.3 × 10−05 |
