Fig. 2 | Nature Communications

Fig. 2

From: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Fig. 2

Usp12 overexpression is not a generic suppressor of neurotoxicity. a–c Cumulative risk of death plots for primary neurons co-transfected with control, TDP-43 (a), TDP-43A315T (b), α-synuclein (c), and Usp12 or empty vector control plasmids. Cox proportional hazards analysis was used to estimate the relative risk of death, or hazard ratio (HR), and the p value was determined with the log rank test (***p < 0.001) (Supplementary Table 4)

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