Table 1 Cox proportional hazards analysis of the effects of Usp12 knockdown or overexpression on survival of rodent primary neurons

Usp12 knockdown

HTT-N568^Q17 + nt-shRNA

Reference

–

–

222

HTT-N568^Q17 + Usp12-shRNA^r

0.94

0.69–1.27

0.67050

141

mHTT-N586^Q138 + nt-shRNA

1.58

1.23–2.05

0.00042

207

mHTT-N586^Q138 + Usp12-shRNA^r

2.00

1.56–2.57

4.27e-08

209

Usp12 overexpression

HTT-N568^Q17 + control vector

Reference

–

–

196

HTT-N568^Q17 + Usp12

1.41

0.98–2.03

0.06154

190

mHTT-N586^Q138 + control vector

2.27

1.63–3.18

1.47e-06

199

mHTT-N586^Q138 + Usp12

1.64

1.15–2.34

0.00604

189

HTT-N568^Q17 + control vector

0.44

0.31–0.61

1.47e-06

196

HTT-N568^Q17 + Usp12

0.62

0.45–0.84

0.00229

190

mHTT-N586^Q138 + control vector

Reference

–

–

199

mHTT-N586^Q138 + Usp12

0.72

0.53–0.97

0.03165

189