Table 1 Comparison of kon and koff values obtained using the tracers F-PPHT and F-clozapine

From: Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

 

F-PPHT

F-Clozapine

Compound

koff (min−1)

kon (M−1 min−1)

koff (min−1)

kon (M−1 min−1)

Remoxipride

1.90 ± 0.55

1.16 ± 0.37 × 107

1.63 ± 0.16

1.00 ± 0.27 × 107

Clozapine

1.67 ± 0.25

8.23 ± 1.42 × 107

1.78 ± 0.28

4.84 ± 1.02 × 107

  1. F-Clozapine’s association rate was measured at 2.71 × 106 M−1 min−1 with a koff value of 0.79 min−1 at 37 °C in HBSS. PPHT-red experiments were performed, as previously described (Sykes et al.2)
  2. Data are mean ± SEM from 3 to 4 experiments
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