Fig. 6
From: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
T cells are involved in retinal neurodegeneration in human glaucoma patients. a, b Comparison of frequencies of HSP27- and HSP60-specific T cells among healthy individuals and patients with POAG or other diseases. Peripheral blood mononuclear cells from patients with POAG (n = 18), NTG (n = 3), retinal detachment (RD; n = 6), skin injuries (SD; n = 8), and age-matched healthy controls (Norm; n = 16) were stimulated with HSP27 (a) or HSP60 (b). Two days later, the frequencies of IFN-γ-secreting cells were determined by ELISPOT. *P < 0.05 by ANOVA. c, d Comparison of serum levels of HSP27- and HSP60-specific IgGs between healthy individuals and patients with POAG or NTG. Sera from POAG (n = 18), NTG (n = 3), and age-matched healthy individuals (Norm, n = 16) were assayed for HSP27- and HSP60-specific IgG by ELISA. *P < 0.05 by ANOVA
