Table 3 Acylation of a series of Beltide-1 derivatives with 4-methoxy phenyl ester 18a
From: Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence
Peptide | N-Terminal mono-acylated product (%) | Di-acylated product (%) |
|---|---|---|
Beltide-1 (13) | No reaction | No reaction |
Ac-Beltide-1 (13-Ac) | − | No reaction |
GHHH-Beltide-1 (14) | 63 | 13 |
GHHHHHH-Beltide-1 (15) | 92 | 8 (±1) |
Ac-GHHHHHH-Beltide-1 (15Ac) | − | 9 (±0.5) |
GHHHHHHG-Beltide-1 (15G) | 97 | 3 (±0.5) |
GHHHHHHK-Beltide-1 (15K) | 87 | 13 (±1) |
Ac-GHHHHHHK-Beltide-1 (15K-Ac) | − | 31 (±4) |
