Fig. 5

Kaplan−Meier survival analysis of IHC and clinical outcomes. Overall survival (OS), disease-free survival (DFS) and specific survival (SS) were available in relation to a second primary tumor, local, locoregional or lymph node relapse. a Patients with lower CSTB expression in the ITF had a higher risk of local relapse and worse survival (P value < 0.05, log-rank test). In addition, a lower NDRG1 expression in the ITF was associated with a higher risk of the patient presenting a second primary tumor and a worse DFS (P value < 0.05, log-rank test). Equal expression between the ITF and the inner tumor or higher CSTB and NDRG1 expression in the ITF did not influence the local relapse or second primary tumor. Patients with higher PGK1 expression in the ITF had a worse survival and early locoregional recurrence (P value < 0.05, log-rank test). b Patients with higher expression of ITGAV in the ITF have a greater risk to present lymph node metastasis relapse and poor survival (P value < 0.05, log-rank test)