Fig. 1
From: The first transmembrane region of complement component-9 acts as a brake on its self-assembly
The X-ray crystal structure of complement component 9. a The X-ray structure of C9 shown in cartoon in two orientations, rotated 180° apart. The bent β-sheet of the MACPF domain is shown in red with α-helices in blue, TMH1 (green) and TMH2 (yellow). The ancillary domains: TSP1 (purple), LDLRA (pink) and EGF domain (orange). Domain colours also match the colours used to show the domain features in Supplementary Fig. 2. b Cartoon model of C9 with the modelled TMH1 loop (green surface) and N-glycan (PDB ID 1HD4) located on the elongation face of the protein. The key features of the MACPF domain are shown as cartoon and coloured as follows: central β-sheet (red), TMH 1 (green), TMH2 (yellow), HTH (blue). c The C8β structure in the same orientation as C9 showing the TMH1 domain on the docking interface (PDB ID 3OJY)
