Fig. 4
From: The first transmembrane region of complement component-9 acts as a brake on its self-assembly
Schematic diagram of the unidirectional C9 assembly. We hypothesise that during the assembly, binding to the elongation face of a C9 subunit leads to the release of TMH1 which inserts to form a canonical β-hairpin. Following this, the release of TMH2 and a conformational change in the HTH region uncovers the elongation face of the newly assembled C9, allowing the next C9 subunit to join the assembly
