Fig. 3 | Nature Communications

Fig. 3

From: Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

Fig. 3

Microscopic biodistribution in breast cancer tissue of bevacizumab-800CW based on micro-segmentation analyses. The upper row shows a representative example of the region-of-interest per tissue type based on H/E staining. The lower row shows the corresponding pseudo color fluorescence intensity image of each tissue type. In a, b the whole section is depicted, and in c, d the tumor area, e, f parenchymal breast tissue including collagen, g, h fat tissue, i, j carcinoma in situ tissue, and a combination of all tissue types in k, l. Mean fluorescence intensities of all patients per dose group, per tissue type are shown in panel m. Asterisk denotes significant (P < 0.05, Kruskal–Wallis test) values. Obelisk denotes significant (P < 0.05, Mann–Whitney U-test) values. Bars are representing the median, error bars are representing 95% confidence interval. Scale bars represent 5 mm

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