Fig. 2
From: Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection
Correlation between serum viral load and virus-specific antibodies. a Serum viral load of 17 survived and 10 deceased patients at different day point was determined by RT-PCR, and then their kenetics of viremia during acute phase of SFTS was generated in the left panel. The level of serum viral load of the survived and deceased group during the 3-week clinical course was compared using T test in the right panel, ** p < 0.005. b Linear regression analysis of correlations between viral load and NP-specific antibodies. X-axis denotes the dilution fold of the patients’ serum samples that gives detectable signal of NP-specific antibodies, and negative means undetectable antibodies at any dilution fold. r and p indicate the correlation coefficient and the p value of significance, respectively. p < 0.05 is considered as significant. c Neutralization of SFTSV by sera from the Gn-immunized camel, convalescent and fatal patients were shown by fluorescence staining (left panel), and percentage of infection reduction as indicated in 50% FRNT value (right panel). Non-specific neutralization effects of both human and camel sera were shown in blue. The data were from two independent experiments, and each data point from duplicate wells (means ± s.e.m). Error bar represents the standard deviation
