Fig. 3
From: Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
PRR7 regulates excitatory synaptic transmission of local hippocampal neurons. a–c Effect of various PRR7 constructs on AMPAR-mediated mEPSCs in dissociated hippocampal neuron culture. Representative traces (a) and quantification of mEPSC amplitude (b) and frequency (c). n = 14–21. d, e Effect of various PRR7 constructs on evoked EPSCs measured by simultaneous whole-cell recordings from Txf and Nxf neurons of CA1 pyramidal cells in organotypic hippocampal slice culture. n = 12–16. Data are represented as scattered plots showing individual data points and mean ± SEM. Two-way ANOVA, post hoc Tukey’s test: F4,150 = 46.2 (b), F4,143 = 85.45 (c), and F4,129 = 81.24 (e). ***P < 0.0001, **P < 0.001, *P < 0.01, and ns not significant
