Fig. 6
From: Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality
myo1d functions to regulate KV lumen expansion, a key event in establishing proper laterality in zebrafish. A model depicting the role of Myo1d and Cftr in KV lumen expansion. When Myo1d mediated vacuole delivery and Cftr channel are active, proper AP cell morphology and threshold lumen expansion with a definitive spherical shape are established by 8S. In the absence of Myo1d, despite CFTR channel being present, KV lumen fails to generate a spherical shape and proper size. This is due to the failure of vacuole trafficking towards apical surface of the KV
