Fig. 5 | Nature Communications

Fig. 5

From: Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Fig. 5

SuStaIn subtyping and staging of genetic frontotemporal dementia and Alzheimer’s disease. a, b The assignability of the disease subtypes estimated by SuStaIn for genetic frontotemporal dementia, and Alzheimer’s disease. Each scatter plot visualises the probability that each individual belongs to each of the SuStaIn subtypes estimated for a genetic frontotemporal dementia (as shown in Fig. 2a), and b. Alzheimer’s disease (as shown in Fig. 3). In the triangle scatter plots, each of the corners corresponds to a probability of 1 of belonging to that subtype, and 0 for the other subtypes; the centre point of the triangle corresponds to a probability of 1/3 of belonging to each subtype. c, d The probability subjects from each of the diagnostic groups belong to each of the SuStaIn stages for c genetic frontotemporal dementia and d Alzheimer’s disease. CN = cognitively normal; MCI = mild cognitive impairment; AD = Alzheimer’s disease

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