Fig. 2

Inhibition of Group I Paks activity by PID retards tumor progression. a Body weights of CDX2;APC;PID (experimental, n = 15) and CDX2;APC (control, n = 21) mice was measured once every two weeks for 8 months. b Number of tumors per mouse were counted from control and experimental mice at 8 months of age, at which time these animals were sacrificed. c Adenoma number found in the intestinal tracts from both cohorts of animals at 8 months of age. d Adenocarcinoma number found in the intestinal tracts from both cohorts of mice at 8 months of age. e Tumor size was measured on paraffin-embedded sections stained for H&E collected from both groups of animals. f Representative H&E staining image of colon tumor dissected from CDX2;APC;PID and CDX2; APC mice (x20 magnification). Bar, 100 μm