Table 1 GCF- IL-1β levels among IL-37 variants haplotypes

From: GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

Variant 1a Rs3811046

Variant 2b Rs2723187

N

Mean GCF IL-1β ng/ml (StErr)

1.1 (TT)

1.1 (CC)

2181

134.5 (3.12)

1.1 (TT)

1.2 (CT)

0

—

1.1 (TT)

2.2 (TT)

0

—

1.2 (TG)

1.1 (CC)

1304

161.0 (4.03)*

1.2 (TG)

1.2 (CT)

515

163.7 (6.42)*

1.2 (TG)

2.2 (TT)

0

—

2.2 (GG)

1.1 (CC)

221

186.8 (9.80)*,***

2.2 (GG)

1.2 (CT)

155

172.3 (11.70) **,****

2.2 (GG)

2.2 (TT)

32

253.7 (25.75) *,*****,#,##

  1. aIL37 Variant 1, lead SNP rs3811046- 1.1 (TT), 1.2 (TG), 2.2 (GG)
  2. bIL37 Variant 2 lead SNP rs2723187- 1.1 (CC) 1.2 (CT), 2.2 (TT)
  3. Overall p value (GLM) < 0.0001
  4. Pairwise p values compared to 1.1/1.1—*p < 0.0001 **p = 0.0018
  5. Pairwise p values compared to 1.2/1.1 or 1.2/1.2—***p = 0.01, ****p = 0.004, *****p = 0.0004
  6. Pairwise p values compared to 2.2/1.1 #p = 0.015, compared to 2.2/1.2 ##p = 0.004
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