Table 2 Association of rs3811046 with chronic and aggressive periodontitis

From: GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation

Periodontitis diagnosis

N

Odds ratio (95% CI)

Dental ARIC PPC-A (Health)

n = 1461

Referent

Dental ARIC PPC-B (Mild disease)

n = 811

1.10 (0.92–1.32)

Dental ARIC PPC-C (High Gingival Index)

n = 158

1.20 (0.86–1.68)

Dental ARIC PPC-D (Tooth Loss)

n = 530

1.10 (0.89–1.35)

Dental ARIC PPC-E (Posterior Disease)

n = 827

1.01 (0.84–1.21)

Dental ARIC PPC-F (Severe tooth Loss)

n = 474

1.14 (0.91–1.42)

Dental ARIC PPC-G (Severe Disease)

n = 237

1.50 (1.12–2.00)

German/Dutch -Healthy controls

n = 4210

Referent

German/Dutch -Aggressive Periodontitis

n = 717

1.12 (1.01–1.26)

  1. Adjusted for Examination Center, Gender, Age, Diabetes, Smoking (5-levels) and 10 Ancestry PC’s
  2. Rs3811046 genotype: 1.1 (TT) vs 1.2 (TG + 2.2 GG)
  3. Chronic periodontitis: in the Dental ARIC cohort
  4. Aggressive periodontitis: in the German/Dutch sample
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