Fig. 6 | Nature Communications

Fig. 6

From: Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems

Fig. 6

Model of targeting discrimination of secreted transmembrane proteins The semi-hydrophobic nature of most TMS of type III-secreted and type IVB-secreted transmembrane proteins prevents recruitment of SRP and erroneous targeting to the Sec-translocon. In addition, specific T3SS chaperones bind TMS of type III-secreted transmembrane proteins and thus shield these segments from wrong targeting factors and aggregation. T4BSS can also accept strongly hydrophobic substrates from within the bacterial inner membrane. HM host membrane, IM inner membrane, OM outer membrane

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