Fig. 7
From: EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
T-cells in UC specimens with higher EMT/Stroma-related gene expression are more frequently localized to the peritumoral stroma. Boxplots of the density of a intratumoral or b peritumoral-stroma CD8 cells in specimens (n = 21), by EMT/Stroma_core gene expression category (≥ or < median level); c Ratio of peritumoral stroma CD8 cells to intratumoral CD8 cells; d, e Representative tumor specimen with low intratumoral CD8 cells and high peritumoral stromal CD8 infiltrates, and f, g with high total and intratumoral CD8 cells. Yellow-shaded zones in images d and f identify tumor areas, whereas the rest represent adjacent stroma. Scale bars correspond to 200 μm. In boxplots, boxes extend from the first to third quartiles, middle line shows median, whiskers extend up to 1.5 times the interquartile range from the top and bottom of the box to the furthest data within that distance. Data beyond the end of the whiskers are “outlying” points. In a and b, filled circles show individual values. In c, the outlying point with extreme value is boxed with a break in the Y axis to better display the entire distribution of the data. Two lines at the end of the whiskers correspond to the maximum and minimum of the data points with the extreme outlier removed
