Fig. 2
From: A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
Correlation of module expression with seizures. a For each co-expression module from the epileptic mouse hippocampus, we plotted the significance (−Log10 FDR) of the Spearman’s correlation between the module’s eigengene and seizure frequency (bar plot), and the percentage of variance in seizure frequency explained by the module’s eigengene (R2, dotted line). Modules marked with a blue arrow are the modules differentially co-expressed between the epileptic mouse hippocampus and the control mouse hippocampus. Modules highlighted in gray (bar plot) are significantly (FDR <0.05) correlated with seizure frequency. b Volcano plot of average (Spearman’s) correlation of a module’s genes with seizure frequency (X-axis) versus the significance of the module’s enrichment for genes individually correlated with seizure frequency (QTT genes) (Y-axis) for the nine modules differentially co-expressed in epilepsy and correlated with seizures by module eigenegene
