Table 1 Causal reasoning rules for membrane receptor effects on target gene expression
From: A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
Receptor | Transcription factor | Target genes |
|---|---|---|
Act (+) | Act (+) | Activated |
Act (+) | Inh (−) | Inhibited |
Inh (−) | Act (+) | Activated |
Inh (−) | Inh (−) | Activated |
