Fig. 7
From: Microbial metabolite sensor GPR43 controls severity of experimental GVHD
Model illustrating role of GPR43 on IECs after allo-BMT. In the context of injury and inflammation caused by alloreactive T cells and PAMPs such as LPS, SCFAs engage GPR43 and promote ERK phosphorylation dependent activation of NLRP3 in IECs that protects them and mitigates damage induced by GVHD (left). Reduction in expression of GPR43 reduces ERK phosphorylation dependent activation of NLRP3 and aggravates GVHD induced IEC damage and barrier breach allowing for greater translocation of PAMPs such as LPS which further amplify the inflammation and damage (right)
