Fig. 2

Microbiome dysbiosis in Nlrp1^−/− mice is transferred to co-housed WT mice. a WT and Nlrp1^−/− littermates were separated at weening for 6 weeks, then stool was collected and subjected to bacterial 16S analysis. Differentially abundant OTUs are presented. b WT mice were either single-housed or co-housed (CH) with Nlrp1^−/− mice for 4 weeks prior to DSS treatment and weight loss, c colon length and d histology score were measured for signs of disease. e Prior to DSS treatment fecal samples were collected for bacterial 16S analysis. Comparison of 16S sequencing showing differentially abundant OTUs in 3 pair-wise comparisons made to WT mice. Data are representative of 2 independent experiments with 3–6 mice per group. Means ± SD (a, e), means ± SEM (b–d); *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. As determined by a two-tailed, unpaired t-test