Fig. 5

Deletion of IL-18 removes the hyper-activated Nlrp1 DSS-induced colitis phenotype. Il-1r^−/−Il-18^−/−Nlrp1a^Q593P/+ and Il-1r^−/−Il-18^−/−Nlrp1a^Q593P/Q593P mice were given 3% (w/v) DSS for 6 days. a The percentage weight loss, b colon length and c histology score for epithelial damage and inflammatory cell infiltrate of H&E-stained sections from the colon were measured for disease severity. d Representative H&E-stained sections of the distal colon from Il-1r^−/−Il-18^−/−Nlrp1a^Q593P/+ and Il-1r^−/−Il-18^−/−Nlrp1a^Q593P/Q593P mice, scale bar = 1 mm. Data are representative of 2 independent experiments with 3–5 mice per group. Means ± SEM