Fig. 6
From: NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
NLRP1 gene expression is augmented in human ulcerative colitis which positively correlates with IFNγ gene expression in inflamed regions of the colon. Microarray analyses were performed on colon biopsies from healthy controls (n = 22), and patients with ulcerative colitis or Crohn’s disease. Gene expression data expressed as relative fold change compared to healthy controls from a transverse (n = 15), cecum (n = 10), sigmoid (n = 32) and rectum (n = 29) regions of the colon from patients with ulcerative colitis and b ileum (n = 25) from patients with Crohn’s disease. Correlation between NLRP1 and IFNγ gene expression in various regions of the colon of c inflamed regions from ulcerative colitis patients. Means ± 95% asymmetric confidence interval; **p ≤ 0.01. A one-way ANOVA and Tukey’s post-hoc comparisons were performed on data that involved more than two comparisons, while a two-tailed, unpaired t-test was performed on data containing two comparisons. Pearson's correlation coefficient was used to generate the r value and the p values denoting the significance were estimated from a paired t-test
