Fig. 9 | Nature Communications

Fig. 9

From: USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Fig. 9

Schematic summary of the role of USP24 in IL-6 mediated metastasis and angiogenesis. USP24 promotes IL-6 expression by increasing the levels of NF-κB and histone H3 acetylation through stabilizes p300 in the M2 macrophages. In lung cancer cells, USP24 increases p300 and β-TrCP levels which promotes histone H3 acetylation, NF-κB nuclear translocation and decreases IL-6 promoter methylation, thus resulting in the upregulation of IL-6 level in tumor-associated microenvironment and lung cancer malignancy

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