Table 5 Enrichment analysis of genes that can extend yeast replicative lifespan in hotspots
From: Temporal genetic association and temporal genetic causality methods for dissecting complex networks
Hotspot | T0 | MPTGA | UNION | REGRESSION | FISHER | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
CHR | Pos | Fold enrichment | p-value | Fold enrichment | p-value | Fold enrichment | p-value | Fold Enrichment | p-value | Fold Enrichment | p-value |
1 | 50,000 | 0a | 1 | NA | NA | NA | NA | NA | NA | NA | NA |
1 | 190,000 | 1.37 | 0.43 | NA | NA | NA | NA | NA | NA | NA | NA |
2 | 430,000 | 0a | 1 | NA | NA | NA | NA | 1.63 | 0.28 | NA | NA |
2 | 550,000 | 0.72a | 0.91 | 1.77 | 3.27E−5b | 0.98 | 0.57 | 1.14 | 0.24 | 0.97 | 0.6 |
3 | 90,000 | 0.4a | 1 | 0 | 1 | 0.6 | 1 | 0.68 | 0.82 | 0 | 1 |
3 | 170,000 | 0 | 1 | NA | NA | NA | NA | 0 | 1 | 0 | 1 |
4 | 90,000 | NA | NA | 3.04c | 0.004b | NA | NA | 0c | 1 | NA | NA |
5 | 190,000 | NA | NA | 4.29c | 1.29E−11b | NA | NA | 5.04c | 2.81E−6b | NA | NA |
5 | 330,000 | NA | NA | NA | NA | NA | NA | 0.86 | 1 | NA | NA |
7 | 410,000 | 2.79 | 0.03 | 1.67 | 0.27 | 1.89 | 0.21 | NA | NA | NA | NA |
8 | 110,000 | 0a | 1 | 0.47 | 0.98 | 0.2 | 1 | 0.22 | 1 | 0.28 | 1 |
9 | 70,000 | NA | NA | 4.42c | 1.20E−5b | NA | NA | NA | NA | NA | NA |
9 | 250,000 | NA | NA | NA | NA | NA | NA | 0.89c | 1 | NA | NA |
12 | 670,000 | 0.99a | 0.55 | 0.98 | 0.58 | 1.14 | 0.35 | 1.17 | 0.32 | 1.35 | 0.15 |
13 | 70,000 | 0.5a | 0.97 | 0.61 | 0.94 | 0.83 | 0.74 | 0.88 | 0.68 | 0.84 | 0.73 |
13 | 910,000 | 2.28 | 0.1 | NA | NA | NA | NA | 3.69 | 0.02 | NA | NA |
14 | 490,000 | 1.13a | 0.42 | NA | NA | NA | NA | 1.56 | 0.3 | NA | NA |
15 | 150,000 | 0.89a | 0.74 | 1.25 | 0.05 | 0.87 | 0.87 | 0.87 | 0.81 | 0.83 | 0.91 |
16 | 510,000 | 1.39a | 0.22 | 2 | 0.01 | 0.92 | 0.65 | 0.98 | 0.58 | 0.72 | 0.78 |
