Fig. 5
Individual observation (dots) and median model predictions (line) in animals left untreated (black) or treated with 180 mg kg−1 BID favipiravir (red). Top left: Ebola virus viral load; top middle CD8 T cells expressing perforin; top right: model prediction of productive infected cell elimination rate, increasing concomitantly to adaptive response; middle left: IFNα concentrations; middle: IL6 concentration; middle right: TNFα concentration; bottom left: predicted ratio of protected cells on the concentration of IFNα (R/F); bottom middle: model prediction of the ratio of infected on protected cells (R/I2); bottom right: Kaplan Meier curves and survival rate prediction. Shaded areas represent the predictions within the 10th and 90th percentiles of 1000 simulations
