Table 1 Parameter estimates of the final viro-immunologic model of Ebola virus disease in cynomolgus macaques
Parameter | Name | Unit | Fixed effect | sd of the random effect | ||
|---|---|---|---|---|---|---|
Estimate | r.s.e.(%) | Estimate | r.s.e.(%) | |||
Baseline clearance rate of productively infected cells | δ | Per day | 0.224 | 9 | 0.169 | 40 |
Viral production | p | Virion per cell per day | 4.15×104 | 71 | 1.76 | 18 |
Clearance rate of virions | c | Per day | 20 | – | 0 | – |
Initial number of target cells | T 0 | Cells per mL | 108 | – | 0 | – |
Inoculum size | V 0 | Virion per mL | 10−4.1 | 11 | 1.5 | 17 |
Virion infectivity | β | mL per virion per day | 7.9×10−11 | 73 | 0 | – |
Rate of transition to productively infected cells | k | Per day | 4 | – | 0 | – |
Favipiravir maximal effect | E max | 1 | – | 0 | – | |
Drug concentration giving 50% of maximal effect | EC50 | µg per mL | 191 | 20 | 0 | – |
IFNα production rate | q | pg per cell per day | 0.0074 | 69 | 0 | – |
IFNα elimination rate | d F | Per day | 0.4 | – | 0 | – |
IFNα concentration giving 50% of max effect | θ T | pg per mL | 1.73 | 35 | 1.05 | 16 |
Maximal rate of transition from target to refractory cells | ϕ | mL pg per day | 2.67 | 17 | 0 | – |
CD8 T cell perforin+ baseline value | C 0 | Cell per mL | 36,900 | 30 | 0.775 | 23 |
Initial proportion of EBOV-specific CD8 T cell perforin+ | P 0 | 0.001 | – | 0 | – | |
CD8 T cell perforin+ elimination rate | δ E | Per day | 0.001 | – | 0 | – |
CD8 T cell perforin+ elimination rate mediated by viremia | ζ | mL per virion per day | 0.455 | 41 | 0 | – |
Specific CD8 T cell perforin+ growth constant | ρ | Per day | 0.338 | 11 | 0 | – |
Non specific CD8 T cell perforin+ growth constant | σ | cell per mL per day | 3050 | 87 | 0 | – |
IFNα concentration providing 50% of max effect on CD8 T cell perforin+ depletion | θ E | pg per mL | 6.5×10−4 | 233 | 0 | – |
CD8 T cell perforin+ mediated infected cell elimination rate | κ | Per day per cell per mL | 2.08×10−5 | 31 | 0 | – |
IL6 production rate | q L | pg per cell day | 0.0097 | 65 | 0.76 | 37 |
IL6 elimination rate | d L | Per day | 0.4 | – | 0 | – |
TNFα production rate | q N | pg per cell per day | 0.0046 | 69 | 1.03 | 30 |
TNFα elimination rate | d N | Per day | 0.4 | – | 0 | – |
Maximal hazard of death | λ m | Per day | 1.12 | 2 | 0 | – |
IFNα effect compartment concentration inducing 50% of the maximal hazard | F 50 | pg per mL | 103 | 12 | 0 | – |
Transfer constant | k s | Per day | 0.319 | 3 | 0 | – |
Hill coefficient | γ | 2 | – | – | – | |
