Table 1 Genome-wide significant results from the meta-analyses of lateral ventricular volume

SNP	Chr	Annotation	Gene(s)	A1/A2	Stage 1		Stage 2		Stage 3 combined
SNP	Chr	Annotation	Gene(s)	A1/A2	Zscore	P	Zscore	P	Zscore	P
rs34113929^a	3q28	intergenic	SNAR-I,OSTN	A/G	−6.84	7.70E−12	−5.05	4.44E−07	−8.27	1.37E−16
rs9937293^a	16q24.2	intergenic	FOXL1,C16orf95	A/G	5.65	1.63E−08	5.61	2.03E−08	7.84	4.45E−15
7:2760334:C_CT^a	7p22.3	intergenic	AMZ1,GNA12	D/I	−5.88	4.21E−09	−4.48	7.34E−06	−7.21	5.61E−13
rs12146713	12q23.3	intronic	NUAK1	T/C	−5.01	5.57E−07	−5.44	5.32E−08	−7.28	3.25E−13
rs4820299	22q13.1	intronic	TRIOBP	T/C	−4.79	1.71E−06	-4.49	7.04E−06	−6.46	1.05E−10
rs35587371	10p12.31	intronic	MLLT10	A/T	−4.89	1.03E−06	−3.32	9.12E−04	−5.61	2.07E−08
rs7936534	11q23.1	intergenic	ARHGAP20,C11orf53	A/G	4.25	2.12E−05	3.71	2.04E−04	5.54	2.96E−08

Variant that showed the lowest p-value in the fixed effect sample-size weighted Z-score meta-analysis for each locus is shown
SNP: single-nucleotide polymorphism, Chr: chromosome, A1/A2: effect allele/other allele, Freq: frequency of effect allele, Zscore: Z score from METAL, P: p-value
^aVariants that surpassed genome-wide significance threshold in stage 1 meta-analysis; remaining SNPs listed in the table reached genome-wide significance threshold in combined, stage 3, meta-analysis

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