Fig. 6
From: A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Proposed model for the assembly and recruitment of the variant PWWP2A/B-NuRD complexes. a The NuRD-family of HDAC complexes assemble around the MTA1/2/3:HDAC1/2:RBBP4/7 subcomplex. PWWP2A/B and MBD2/3 bind to the deacetylase subcomplex in a mutually exclusive manner. Canonical NuRD components p66α/β and CHD3/4 can only associate with the MBD2/3 containing complex. b SETD2 deposits H3K36me3 over gene body regions co-transcriptionally. PWWP2A/B recruits HDAC activity to the gene bodies of highly expressed genes through binding to H3K36me3. Both canonical NuRD and the PWWP2A/B HDAC complexes are recruited to regulatory promoter regions, but their activity is antagonised by HAT complexes which are also enriched at promoter regions. The regulation of histone acetylation at active genes facilitates RNA Pol II transcriptional elongation
