Fig. 2

Gene expression changes in T2D human islets. a Stimulation index of isolated human islets in response to glucose among the three defined groups. b Donor Hba1c levels among the three groups, dotted lines indicate the levels of normal (below 5.7%), pre-diabetic (5.7–6.5%) and diabetic (above 6.5%) individuals. c BCL11A mRNA expression across the three groups. d INSULIN mRNA expression across the three groups. e GLUT1 mRNA expression across the three groups. See also Supplementary Figure 2. The data obtained from a total of 30 donors (10 per group), presented as boxplots, center line represents the mean, whiskers represent the minimum and maximum points, and two-tailed t tests were used to generate p values. *p < 0.05, **p < 0.01, ***p < 0.001