Fig. 3
From: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Predicted expression of MLPH explains majority of GWAS signal at its genomic region. Each point corresponds to the association between SNP and PrCa status. Gray points indicate the marginal association of a SNP with PrCa status (i.e., GWAS association). Green points indicate the association of the same SNPs with PrCa after conditioning on predicted expression of MLPH using models trained from normal prostate (GTEx) and tumor prostate (TCGA). The dashed gray line corresponds to the genome-wide significant threshold (i.e., P = 5 × 10−8). MLPH was discussed in previous works as a possible susceptibility gene for PrCa. Association between total expression of MLPH and PrCa risk was transcriptome-wide significant in normal and tumor prostate tissue
