Table 1 Novel risk loci

From: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Gene

Chr

Tx start

Tx end

Exon/exon junction

Expression reference

Best GWAS SNP

Best GWAS P

TWAS P

GRHL3

1

24645811

24690970

TCGA.PRAD.TUMOR

rs11589294

1.49E−05

9.38E−10*

GRHL3

   

24668763:24669184

TCGA.PRAD_SP.TUMOR

  

3.08E−07

FAM83H

8

49396578

49449526

CMC.BRAIN.RNASEQ

rs7831467

3.32E−06

1.66E−07*

TLE4

9

82186687

82341796

82189851:82191048

TCGA.PRAD_SP.TUMOR

rs10117770

2.47E−07

2.94E−07*

TLE4

   

TCGA.PRAD.TUMOR

  

1.46E−07*

TLE4

   

82268990:82319698

TCGA.PRAD_SP.TUMOR

  

1.25E−07*

TLE4

   

82319817:82320804

TCGA.PRAD_SP.TUMOR

  

2.43E−07*

TLE4

   

82320857:82321662

TCGA.PRAD_SP.TUMOR

  

2.57E−07*

TLE4

   

82321814:82323033

TCGA.PRAD_SP.TUMOR

  

2.43E−07*

TLE4

   

82323165:82323508

TCGA.PRAD_SP.TUMOR

  

2.88E−07*

TLE4

   

82323701:82324538

TCGA.PRAD_SP.TUMOR

  

2.43E−07*

TLE4

   

82324614:82333637

TCGA.PRAD_SP.TUMOR

  

2.77E−07*

TLE4

   

82333886:82334961

TCGA.PRAD_SP.TUMOR

  

8.77E−08*

TLE4

   

82335208:82336656

TCGA.PRAD_SP.TUMOR

  

3.06E−07*

TLE4

   

82336803:82337366

TCGA.PRAD_SP.TUMOR

  

1.29E−07*

TLE4

   

82337516:82337874

TCGA.PRAD_SP.TUMOR

  

2.42E−07*

TLE4

   

82337950:82339952

TCGA.PRAD_SP.TUMOR

  

2.43E−07*

STXBP1

9

130374485

130454995

TCGA.PRAD.TUMOR

rs1318074

1.79E−07

2.92E−07*

STXBP1

   

130374719:130413882

TCGA.PRAD_SP.TUMOR

  

1.88E−07*

STXBP1

   

130413931:130415994

TCGA.PRAD_SP.TUMOR

  

2.56E−07*

STXBP1

   

130416075:130420654

TCGA.PRAD_SP.TUMOR

  

2.16E−07*

STXBP1

   

130420730:130422309

TCGA.PRAD_SP.TUMOR

  

1.39E−07*

STXBP1

   

130422387:130423381

TCGA.PRAD_SP.TUMOR

  

4.10E−07*

STXBP1

   

130423484:130425484

TCGA.PRAD_SP.TUMOR

  

2.22E−07*

STXBP1

   

130425632:130427526

TCGA.PRAD_SP.TUMOR

  

2.75E−07*

STXBP1

   

130428575:130430359

TCGA.PRAD_SP.TUMOR

  

2.51E−07*

STXBP1

   

130430466:130432177

TCGA.PRAD_SP.TUMOR

  

2.51E−07*

STXBP1

   

130432237:130434330

TCGA.PRAD_SP.TUMOR

  

2.06E−07*

STXBP1

   

130434395:130435460

TCGA.PRAD_SP.TUMOR

  

1.47E−07*

STXBP1

   

130435540:130438083

TCGA.PRAD_SP.TUMOR

  

2.60E−07*

STXBP1

   

130438221:130438923

TCGA.PRAD_SP.TUMOR

  

3.15E−07*

STXBP1

   

130439032:130440710

TCGA.PRAD_SP.TUMOR

  

1.98E−07*

RP11-57H14.2

10

114710405

114711634

GTEx.Esophagus_Muscularis

rs11196152

1.61E−07

1.40E−07*

RP11-57H14.2

   

GTEx.Lung

  

9.81E−08*

RP11-57H14.2

   

GTEx.Nerve_Tibial

  

3.29E−08*

RP11-57H14.2

   

GTEx.Pituitary

  

1.11E−07*

RP11-57H14.2

   

GTEx.Thyroid

  

3.40E−07*

RP11-57H14.2

   

GTEx.Whole_Blood

  

1.97E−08*

TM7SF3

12

27124505

27167339

27129290:27132717

TCGA.PRAD_SP.TUMOR

rs16931510

3.06E−07

2.27E−07*

POLI

18

51795773

51824604

NTR.BLOOD.RNAARR

rs11083046

5.44E−07

2.29E−08*

POLI

   

GTEx.Adipose_Subcutaneous

  

1.92E−07*

POLI

   

GTEx.Artery_Aorta

  

2.25E−07*

POLI

   

GTEx.Artery_Tibial

  

1.54E−07*

POLI

   

GTEx.Brain_Cerebellar_Hemisphere

  

1.63E−07*

POLI

   

GTEx.Brain_Cerebellum

  

1.56E−07*

POLI

   

GTEx.Brain_Putamen_basal_ganglia

  

3.54E−07*

POLI

   

GTEx.Breast_Mammary_Tissue

  

3.20E−07*

POLI

   

GTEx.Cells_EBV-transformed_lymphocytes

  

1.63E−07*

POLI

   

GTEx.Colon_Sigmoid

  

4.86E−08*

POLI

   

GTEx.Esophagus_Gastroesophageal_Junction

  

1.99E−07*

POLI

   

GTEx.Esophagus_Mucosa

  

2.15E−07*

POLI

   

GTEx.Esophagus_Muscularis

  

2.08E−07*

POLI

   

GTEx.Heart_Atrial_Appendage

  

1.36E−07*

POLI

   

GTEx.Lung

  

4.39E−07*

POLI

   

GTEx.Nerve_Tibial

  

9.62E−08*

POLI

   

GTEx.Spleen

  

2.74E−07*

POLI

   

GTEx.Testis

  

1.43E−07*

POLI

   

GTEx.Thyroid

  

2.34E−08*

POLI

   

GTEx.Whole_Blood

  

4.11E−07*

POLI

   

METSIM.ADIPOSE.RNASEQ

  

3.89E−07*

POLI

   

YFS.BLOOD.RNAARR

  

2.94E−07*

POLI

   

51807273:51809207

TCGA.PRAD_SP.TUMOR

  

4.47E−07*

KDSR

18

60994959

61034743

GTEx.Adipose_Subcutaneous

rs1541296

3.98E−07

4.20E−07*

UQCC1

20

33935075

33954360

33935075:33954360

TCGA.PRAD_SP.TUMOR

rs7280

3.98E−07

4.40E−07*

  1. TWAS associations that did not overlap a genome-wide significant SNP (i.e., ±1 Mb transcription start site). Study denotes the original expression panel used to fit weights. P-value for TWAS computed under the null of no association between gene expression levels and PrCa risk under a Normal (0, 1) distribution. An asterisk (*) indicates associations that are significant (P < 0.05/9) under a permutation test