Table 1 Novel risk loci
From: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
Gene | Chr | Tx start | Tx end | Exon/exon junction | Expression reference | Best GWAS SNP | Best GWAS P | TWAS P |
---|---|---|---|---|---|---|---|---|
GRHL3 | 1 | 24645811 | 24690970 | — | TCGA.PRAD.TUMOR | rs11589294 | 1.49E−05 | 9.38E−10* |
GRHL3 | 24668763:24669184 | TCGA.PRAD_SP.TUMOR | 3.08E−07 | |||||
FAM83H | 8 | 49396578 | 49449526 | — | CMC.BRAIN.RNASEQ | rs7831467 | 3.32E−06 | 1.66E−07* |
TLE4 | 9 | 82186687 | 82341796 | 82189851:82191048 | TCGA.PRAD_SP.TUMOR | rs10117770 | 2.47E−07 | 2.94E−07* |
TLE4 | — | TCGA.PRAD.TUMOR | 1.46E−07* | |||||
TLE4 | 82268990:82319698 | TCGA.PRAD_SP.TUMOR | 1.25E−07* | |||||
TLE4 | 82319817:82320804 | TCGA.PRAD_SP.TUMOR | 2.43E−07* | |||||
TLE4 | 82320857:82321662 | TCGA.PRAD_SP.TUMOR | 2.57E−07* | |||||
TLE4 | 82321814:82323033 | TCGA.PRAD_SP.TUMOR | 2.43E−07* | |||||
TLE4 | 82323165:82323508 | TCGA.PRAD_SP.TUMOR | 2.88E−07* | |||||
TLE4 | 82323701:82324538 | TCGA.PRAD_SP.TUMOR | 2.43E−07* | |||||
TLE4 | 82324614:82333637 | TCGA.PRAD_SP.TUMOR | 2.77E−07* | |||||
TLE4 | 82333886:82334961 | TCGA.PRAD_SP.TUMOR | 8.77E−08* | |||||
TLE4 | 82335208:82336656 | TCGA.PRAD_SP.TUMOR | 3.06E−07* | |||||
TLE4 | 82336803:82337366 | TCGA.PRAD_SP.TUMOR | 1.29E−07* | |||||
TLE4 | 82337516:82337874 | TCGA.PRAD_SP.TUMOR | 2.42E−07* | |||||
TLE4 | 82337950:82339952 | TCGA.PRAD_SP.TUMOR | 2.43E−07* | |||||
STXBP1 | 9 | 130374485 | 130454995 | — | TCGA.PRAD.TUMOR | rs1318074 | 1.79E−07 | 2.92E−07* |
STXBP1 | 130374719:130413882 | TCGA.PRAD_SP.TUMOR | 1.88E−07* | |||||
STXBP1 | 130413931:130415994 | TCGA.PRAD_SP.TUMOR | 2.56E−07* | |||||
STXBP1 | 130416075:130420654 | TCGA.PRAD_SP.TUMOR | 2.16E−07* | |||||
STXBP1 | 130420730:130422309 | TCGA.PRAD_SP.TUMOR | 1.39E−07* | |||||
STXBP1 | 130422387:130423381 | TCGA.PRAD_SP.TUMOR | 4.10E−07* | |||||
STXBP1 | 130423484:130425484 | TCGA.PRAD_SP.TUMOR | 2.22E−07* | |||||
STXBP1 | 130425632:130427526 | TCGA.PRAD_SP.TUMOR | 2.75E−07* | |||||
STXBP1 | 130428575:130430359 | TCGA.PRAD_SP.TUMOR | 2.51E−07* | |||||
STXBP1 | 130430466:130432177 | TCGA.PRAD_SP.TUMOR | 2.51E−07* | |||||
STXBP1 | 130432237:130434330 | TCGA.PRAD_SP.TUMOR | 2.06E−07* | |||||
STXBP1 | 130434395:130435460 | TCGA.PRAD_SP.TUMOR | 1.47E−07* | |||||
STXBP1 | 130435540:130438083 | TCGA.PRAD_SP.TUMOR | 2.60E−07* | |||||
STXBP1 | 130438221:130438923 | TCGA.PRAD_SP.TUMOR | 3.15E−07* | |||||
STXBP1 | 130439032:130440710 | TCGA.PRAD_SP.TUMOR | 1.98E−07* | |||||
RP11-57H14.2 | 10 | 114710405 | 114711634 | — | GTEx.Esophagus_Muscularis | rs11196152 | 1.61E−07 | 1.40E−07* |
RP11-57H14.2 | — | GTEx.Lung | 9.81E−08* | |||||
RP11-57H14.2 | — | GTEx.Nerve_Tibial | 3.29E−08* | |||||
RP11-57H14.2 | — | GTEx.Pituitary | 1.11E−07* | |||||
RP11-57H14.2 | — | GTEx.Thyroid | 3.40E−07* | |||||
RP11-57H14.2 | — | GTEx.Whole_Blood | 1.97E−08* | |||||
TM7SF3 | 12 | 27124505 | 27167339 | 27129290:27132717 | TCGA.PRAD_SP.TUMOR | rs16931510 | 3.06E−07 | 2.27E−07* |
POLI | 18 | 51795773 | 51824604 | — | NTR.BLOOD.RNAARR | rs11083046 | 5.44E−07 | 2.29E−08* |
POLI | — | GTEx.Adipose_Subcutaneous | 1.92E−07* | |||||
POLI | — | GTEx.Artery_Aorta | 2.25E−07* | |||||
POLI | — | GTEx.Artery_Tibial | 1.54E−07* | |||||
POLI | — | GTEx.Brain_Cerebellar_Hemisphere | 1.63E−07* | |||||
POLI | — | GTEx.Brain_Cerebellum | 1.56E−07* | |||||
POLI | — | GTEx.Brain_Putamen_basal_ganglia | 3.54E−07* | |||||
POLI | — | GTEx.Breast_Mammary_Tissue | 3.20E−07* | |||||
POLI | — | GTEx.Cells_EBV-transformed_lymphocytes | 1.63E−07* | |||||
POLI | — | GTEx.Colon_Sigmoid | 4.86E−08* | |||||
POLI | — | GTEx.Esophagus_Gastroesophageal_Junction | 1.99E−07* | |||||
POLI | — | GTEx.Esophagus_Mucosa | 2.15E−07* | |||||
POLI | — | GTEx.Esophagus_Muscularis | 2.08E−07* | |||||
POLI | — | GTEx.Heart_Atrial_Appendage | 1.36E−07* | |||||
POLI | — | GTEx.Lung | 4.39E−07* | |||||
POLI | — | GTEx.Nerve_Tibial | 9.62E−08* | |||||
POLI | — | GTEx.Spleen | 2.74E−07* | |||||
POLI | — | GTEx.Testis | 1.43E−07* | |||||
POLI | — | GTEx.Thyroid | 2.34E−08* | |||||
POLI | — | GTEx.Whole_Blood | 4.11E−07* | |||||
POLI | — | METSIM.ADIPOSE.RNASEQ | 3.89E−07* | |||||
POLI | — | YFS.BLOOD.RNAARR | 2.94E−07* | |||||
POLI | 51807273:51809207 | TCGA.PRAD_SP.TUMOR | 4.47E−07* | |||||
KDSR | 18 | 60994959 | 61034743 | — | GTEx.Adipose_Subcutaneous | rs1541296 | 3.98E−07 | 4.20E−07* |
UQCC1 | 20 | 33935075 | 33954360 | 33935075:33954360 | TCGA.PRAD_SP.TUMOR | rs7280 | 3.98E−07 | 4.40E−07* |