Fig. 5 | Nature Communications

Fig. 5

From: Persistent repair intermediates induce senescence

Fig. 5

Disrupting DNA repair efficiency drives cell cycle exit. a Mitotic entry scored in RPE CCNB1YFP cells within 15 h following IR (2 Gy). Average of three independent experiments + sem. b Percentage of RPE CCNB1YFP cells that translocate Cyclin B1 after IR (2 Gy). Average of three independent experiments + sem. c Induction of GFPp21 expression after IR (2 Gy) upon depletion or inhibition of the indicated repair proteins. Mean lines from pooled individual cells from two independent experiments, n > 50 cells per condition, significance by 2-way ANOVA

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