Fig. 6 | Nature Communications

Fig. 6

From: Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge

Fig. 6

Initial eosinophil recruitment is dynamically regulated by lung DC subsets. After allergen challenge, cDC1s directly recruit eosinophils by secreting CCL17 and CCL22, which are critical for early eosinophil infiltration. This cDC1-mediated eosinophil infiltration is dynamically modulated by other lung DC subsets. After allergen challenge, lung CD24−CD11b+ DC2s promoted eosinophil infiltration by producing NO on day 1.5, which promotes CCL17 and CCL22 expression by cDC1s, whereas CD24+ cDC2s inhibit this process by releasing TGF-β1 on day 2.5

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