Fig. 5
Age-related alterations of lineage-specific proteins in HPCs. a Scatter plot of the relationship between Spearman’s rank correlation coefficient (x-axis) and the corresponding p value of proteins specifically expressed in HPCs (y-axis). The colour assigned to each bubble is indicative of its function, as explained in the upper left legend. The area of the bubbles represents the significance level (p value (−log10)). The stars at the dashed lines indicate a p value of 0.05 (*) and 0.01 (**). b Scatter plot similar to a, with proteins associated with common lymphoid progenitors (CLP) compared to megakaryocytic and erythroid progenitors (MEP), common myeloid progenitors (CMP), and haematopoietic stem cells/multipotent progenitors (HSC/MPP) in accordance with the GO annotation of immune system process (GO:0002376)10. c Significant alterations of the proteome landscape of HPCs upon ageing. Each circle represents a successful quantification in an individual human subject, with the respective age noted at the bottom. The colour codes for the z-score of relative intensity vs. the internal standard (TMT protein ratio), with red indicating an increase and blue a decrease in abundance upon ageing. The boxes indicate the age boundaries where the majority of the respective age-dependent increase or decrease in protein abundance takes place
