Fig. 7
From: Structural basis of neurosteroid anesthetic action on GABAA receptors
Structural changes in the ECD due to different TMDs. a Top view of crystal structures of apo ELIC-α1GABAAR (orange) and apo ELIC (green), aligned along all ECD residues. b Displacements of Cα atoms of equivalent residues in apo ELIC-α1GABAAR and apo ELIC in the pre-TM1 and the TM2–TM3 loop are labeled. Both the pre-TM1 and TM2–TM3 loop regions may affect the ECD. c Structural changes in the ECD are measured by displacements of the highlighted residues in several key regions
