Fig. 2
From: RNA editing derived epitopes function as cancer antigens to elicit immune responses
Response of TILs to CCNI peptides. a ELISPOT (upper) and summary graphs (lower) showing IFNγ production (arithmetic mean and s.e.m., n = 3) by 3 melanoma TILs following incubation with CCNI-ED10 peptide. Only background level of IFNγ-producing TILs were detected when incubated alone or together with CCNI-WT10. b TIL2576 weakly reacted to CCNI-ED9. c Caspase3 based Cytotoxic T Lymphocyte (CTL) killing assay showing TIL2661 mediated killing of T2 cells pulsed with CCNI-ED10 or CCNI-WT. d Overexpression of edited but not wildtype CCNI gene in 293-A2 cells enhanced TIL2678’s CTL killing activity. The error bar represents the standard error of the mean (s.e.m.) of the three replicates
