Table 1 List of HLA-bound edited peptides (ED) and their non-edited (WT) counterparts as identified by MS-based immunopeptidomics from primary human tissue
From: RNA editing derived epitopes function as cancer antigens to elicit immune responses
Editing site (hg19 coordinates) | Gene | Edited peptide (sequence) | Wildtype peptide (sequence) | HLA restriction |
|---|---|---|---|---|
CCNI R75G (chr4:77,979,680) | Cyclin I | CCNI-ED9 (LLDGFLATV) | CCNI-WT9 (LLDRFLATV) | A*02:01 |
CCNI R75G (chr4:77,979,680) | Cyclin I | CCNI-ED10 (SLLDGFLATV) | CCNI-WT10 (SLLDRFLATV) | A*02:01 |
COPA I164V (chr1:160,302,244) | Coatomer subunit alpha | COPA-ED10 (RVWDVSGLRK) | COPA-WT10 (RVWDISGLRK) | A*03:01 |
COPA I164V (chr1:160,302,244) | Coatomer subunit alpha | COPA-ED11 (RVWDVSGLRKK) | COPA-WT11 (RVWDISGLRKK) | A*03:01 |
CDK13 Q35R (chr7:39,990,344) | Cyclin Dependent Kinase 13 | CDK13-ED (SPRQPPLLL) | CDK13-WT (SPQQPPLLL) | B*07:02 |
