Fig. 3 | Nature Communications

Fig. 3

From: Simple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines

Fig. 3

RuCl2(PPh3)3-catalyzed synthesis of branched primary amines from ketones. aReaction conditions: 0.5 mmol ketone, 3 mol% RuCl2(PPh3)3, 5–7 bar NH3, 40 bar H2 1.5 mL t-amyl alcohol, 130 oC, 24 h, isolated yields. bGC yields using n-hexadecane as standard. cSame as ‘a’ with 1 mol% catalyst. dSame as ‘a’ for 30 h. eDiastereomeric ratio. Isolated as free amines and converted to hydrochloride salts. Corresponding hydrochloride salts were subjected to NMR analysis

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